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Year : 2022  |  Volume : 11  |  Issue : 5  |  Page : 18-20

Nitrofurantoin-induced interstitial lung disease

Department of General Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India

Correspondence Address:
Mallikarjuna Shetty
Associate Professor, Department of General Medicine, Nizam's Institute of Medical Sciences, Hyderabad 500 082, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JCSR.JCSR_86_20

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We report the case of a 55-year-old woman diagnosed with interstitial lung disease due to long-term nitrofurantoin therapy that was administered for recurrent urinary tract infection. Despite distorted pulmonary parenchymal architecture and patchy fibrosis confirmed by computed tomography of the thorax, the symptoms and radiographic findings disappeared within 3 months after the administration of prednisone. This case shows that nitrofurantoin-induced lung disease may run a benign course and respond favourably to corticosteroids, even when there is radiographic evidence of established lung fibrosis. This case report highlights the need for vigilance of pulmonary toxicity in patients taking long-term nitrofurantoin therapy.

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