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Year : 2022  |  Volume : 11  |  Issue : 4  |  Page : 234-239

Role of neutrophil-to-lymphocyte ratio in predicting microvascular complications in type 2 diabetes mellitus

1 Department of General Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
2 Department of Respiratory Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
3 Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
4 Department of Biochemistry, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India

Correspondence Address:
Swaroopa Deme
Associate Professor, Department of General Medicine, Nizams Institute of Medical Sciences, Hyderabad 500 082, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcsr.jcsr_24_22

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Background: Tools for early recognition to enable timely intervention and prevention of micro and macrovascular complications are needed in diabetes mellitus. Our study was aimed at assessing the role of neutrophil-to-lymphocyte ratio (NLR) as a tool to identify individuals at risk for microvascular complications in type 2 diabetics, i.e., diabetic nephropathy, retinopathy and neuropathy. Methods: This was a cross-sectional study conducted at a tertiary care hospital in south India that included 98 patients with type 2 diabetes mellitus. NLR was calculated; clinical and laboratory work-up was done in all patients. This was done by quantifying albuminuria by albumin-creatinine ratio (ACR), fundus examination and nerve conduction studies. Correlation between NLR, ACR and other variables was studied in individuals with or without microvascular complications. Results: The NLR in patients with increased ACR was found to be significantly higher when compared to patients with normal ACR (P < 0.001) with a correlation coefficient of 0.783 between ACR and NLR. Receiver operater characteristic curve analysis suggested an NLR cut-off value of 2.032 with a sensitivity and specificity of 89.1% and 81.2%, respectively. A statistically significant higher NLR value was observed in patients with diabetic retinopathy (P = 0.0005) and neuropathy (P < 0.0001). Conclusions: NLR can be used as an early predictor of diabetic nephropathy, neuropathy and retinopathy. It, being an easier tool, can be routinely measured in diabetic individuals to identify at-risk individuals, so that early intervention with appropriate measures can be instituted.

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