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Year : 2022  |  Volume : 11  |  Issue : 3  |  Page : 157-161

Effect of hyperglycaemia on outcome of critically ill patients with and without diabetes mellitus admitted to medical intensive care unit

1 Department of Medicine, Narayana Medical College, Nellore, India
2 Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
3 Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India

Correspondence Address:
Sameeraja Vaddera
Assistant Professor, Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati 517 507, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcsr.jcsr_60_21

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Background: Hyperglycaemia among critically ill patients is associated with nosocomial infections, multi-organ dysfunction and prolonged hospitalisation. Sparse data are available regarding the effect of hyperglycaemia on mortality in medical intensive care unit (MICU) patients in India. Methods: A prospective study was conducted in MICU at a tertiary teaching hospital in Southern India during the period of March 2018–June 2019. Patients were classified as having/not having diabetes mellitus. Blood glucose was monitored in all patients with. Age, severity of critical illness, comorbidities and laboratory variables were recorded. The association of hyperglycaemia with mortality was studied. Results: Patients with diabetes mellitus were older, had more number of comorbidities like hypertension, coronary artery disease compared to those without diabetes mellitus. On logistic regression analysis mean blood glucose did not emerge as an independent determinant of mortality in patients with and without diabetes mellitus. The acute physiology and chronic health evaluation II (APACHE II) score was found to be an independent determinant of mortality in patient with (P = 0.0001) and without (P = 0.0001) diabetes mellitus. Conclusion: Our observations suggest that in critically ill patients with or without diabetes mellitus admitted to MICU, hyperglycaemia was not a predictor of mortality.

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